Quinolines and derivatives
- (1)
- (1)
- (1)
- (224)
- (6)
- (1)
- (1)
- (40)
- (2)
- (12)
- (48)
- (1)
- (37)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (4)
- (1)
- (1)
- (8)
- (135)
- (1)
- (10)
- (16)
- (1)
- (36)
- (1)
- (1)
- (1)
- (1)
- (1)
- (189)
- (1)
- (1)
- (17)
- (1)
- (18)
- (17)
- (6)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (8)
- (21)
- (26)
- (2)
- (30)
- (4)
- (6)
- (1)
- (4)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (5)
- (2)
- (6)
- (5)
- (1)
- (2)
- (1)
- (11)
- (1)
- (2)
- (1)
- (4)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (25)
- (16)
- (2)
- (3)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (4)
- (1)
- (1)
- (4)
- (4)
- (8)
- (2)
- (2)
- (1)
- (1)
- (6)
- (2)
- (1)
- (1)
- (2)
- (1)
- (6)
- (1)
- (20)
- (1)
- (5)
- (1)
- (3)
- (5)
- (1)
- (2)
- (2)
- (2)
- (2)
- (8)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (4)
- (3)
- (1)
- (1)
- (1)
- (4)
- (2)
- (2)
- (1)
- (1)
- (1)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (5)
- (1)
- (1)
- (2)
- (5)
- (2)
- (4)
- (2)
- (3)
- (1)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (4)
- (1)
- (2)
- (4)
- (1)
- (1)
- (3)
- (3)
- (1)
- (7)
- (2)
- (1)
- (4)
- (1)
- (1)
- (1)
- (2)
- (2)
- (4)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (2)
- (3)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (3)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (4)
- (1)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (13)
- (1)
- (1)
- (2)
- (2)
- (4)
- (3)
- (4)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (19)
- (2)
- (1)
- (2)
- (4)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (4)
- (5)
- (1)
- (2)
- (1)
- (1)
- (2)
- (4)
- (3)
- (2)
- (1)
- (9)
- (5)
- (2)
- (3)
- (3)
- (2)
- (5)
- (6)
- (3)
- (13)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (3)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (4)
- (5)
- (4)
- (3)
- (3)
- (7)
- (1)
- (1)
- (2)
- (3)
- (7)
- (5)
- (2)
- (1)
- (10)
- (1)
- (1)
- (1)
- (2)
- (2)
- (4)
- (1)
- (2)
- (2)
- (4)
- (2)
- (2)
- (6)
- (2)
- (7)
- (4)
- (3)
- (2)
- (2)
- (5)
- (2)
- (1)
- (14)
- (1)
- (1)
- (23)
- (42)
- (24)
- (18)
- (83)
- (3)
- (17)
- (3)
- (5)
- (8)
- (1)
- (6)
- (1)
- (5)
- (1)
- (6)
- (5)
- (2)
- (5)
- (2)
- (6)
- (2)
- (2)
- (4)
- (1)
- (25)
- (19)
- (71)
- (1)
- (110)
- (3)
- (1)
- (2)
- (63)
- (5)
- (1)
- (1)
- (2)
- (299)
- (2)
- (2)
- (25)
- (2)
- (5)
- (1)
- (1)
- (1)
- (1)
- (3)
- (9)
- (3)
- (2)
- (62)
- (2)
- (5)
- (29)
- (3)
- (2)
- (1)
- (1)
- (1)
- (3)
- (3)
- (2)
- (1)
- (1)
- (2)
- (1)
- (5)
- (4)
- (2)
- (1)
- (3)
- (1)
- (2)
- (2)
- (5)
- (3)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (12)
- (4)
- (1)
- (5)
- (3)
- (5)
- (2)
- (2)
- (3)
- (2)
- (1)
- (1)
- (3)
- (5)
- (1)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
Filtered Search Results
Apexbio Technology LLC Trospium chloride 10405-02-4 200mg
Trospium chloride (CAS 10405-02-4) is a quaternary ammonium compound that functions as a competitive antagonist at muscarinic acetylcholine receptors thereby inhibiting cholinergic stimulation of the bladder detrusor muscle This action reduces involuntary bladder contractions leading to decreased urinary urgency frequency and urge incontinence Trospium chloride displays pharmacological properties distinct from tertiary amine antimuscarinics including limited central nervous system penetration It is widely utilized in preclinical and clinical research focused on urinary disorders and muscarinic receptor pharmacology
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Tavaborole | 174671-46-6 | 99.7% | 151.93 | 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Tavaborole is an antifungal agent primarily active against Trichophyton species, developed as a topical solution for the treatment of onychomycosis. It is intended strictly for research purposes and not sold to patients.
- Antifungal agent with activity against Trichophyton species.
- Used in a topical solution formulation for the potential treatment of onychomycosis.
- Demonstrates an 8-fold increase in activity against C. neoformans and A. fumigatus in vitro.
- Inhibits cells expressing GlLeuRS-D444A.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC Golvatinib (E7050) 928037-13-2 200mg
Golvatinib (E7050 CAS 928037-13-2) is a small-molecule inhibitor targeting the tyrosine kinases c-Met and VEGFR-2 Golvatinib inhibits phosphorylation of c-Met in MKN45 gastric cancer cells and VEGFR-2 in human umbilical vein endothelial cells (HUVECs) with IC50 values of 14 nM and 16 nM respectively Additionally it suppresses proliferation of various tumor cells including MKN45 EBC-1 Hs746T and SNU-5 and inhibits tumor growth in xenograft models via reduction of c-Met and VEGFR-2-mediated pathways Golvatinib is utilized in cancer research to explore targeted antitumor efficacy related to angiogenesis and oncogenic signaling
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC Sparteine 492-08-0 200mg
Sparteine (CAS 492-08-0) is a naturally occurring alkaloid recognized for its activity as a ganglionic blocker It acts by competitively inhibiting neuronal nicotinic acetylcholine receptors thereby modulating synaptic transmission within the nervous system Owing to this specific mechanism sparteine is widely employed in neurobiological and pharmacological research to investigate neuronal signaling pathways and to elucidate mechanisms involved in central nervous system disorders Its use facilitates the exploration of neurotransmitter regulation and receptor function in experimental models
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Cayman Chemical DImethyl sulfon 5g
An organic sulfur derivative described to have anti-inflammatory and analgesic properties; commonly found as an adulterant in methamphetamine samples
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC D-Pantothenate sodium 867-81-2 200mg
D-Pantothenate sodium (CAS 867-81-2) is a water-soluble small molecule that serves as a biosynthetic precursor to coenzyme A (CoA) Through its conversion to CoA D-pantothenate sodium participates in vital cellular processes involving the metabolism of carbohydrates lipids proteins and nucleic acids It modulates metabolic pathways by influencing the activity of enzymes and associated signaling networks thereby contributing to cellular metabolic regulation This compound is frequently employed in studies investigating cellular metabolism disease models related to metabolic dysfunction and the biochemical mechanisms underlying enzyme-catalyzed reactions
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
eMolecules 252917-06-9 | CHIR-99021 | TargetMol | MFCD11846251 | 465.340 | C22H18Cl2N8 | 0.000 | Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl | 200mg | 845737039
CHIR-99021 | TargetMol | 252917-06-9 | MFCD11846251 | 465.340 | C22H18Cl2N8 | 0.000 | Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl | 200mg | 845737039
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC D4476 301836-43-1 200mg
D4476 (CAS 301836-43-1) is a selective cell-permeable inhibitor of casein kinase 1 (CK1) and ALK5 exhibiting IC50 values of 0 3 M for CK1 and 0 5 M for ALK5 (at 0 1 mM ATP in vitro) It likely acts via ATP-competitive inhibition of CK1 showing minimal to no significant inhibitory activity against SAPK2a/p38 PKB or SGK Treatment with D4476 inhibits CK1-mediated phosphorylation of FOXO1a (Ser322 and Ser325) and RhoB (Ser185) in H4IIE and HeLa cells respectively impacting downstream processes such as nuclear export dynamics and actin cytoskeleton regulation Additionally it induces partial p53-dependent growth arrest in HCT116 cells
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Madecassoside | 34540-22-2 | 975.12 | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica with anti-inflammatory, antioxidant, and anti-aging properties. It is orally active and inhibits inflammation, oxidation, apoptosis, and autophagy by inhibiting p38 MAPK and NF-κB activities, exhibiting anti-apoptotic properties, and activating Nrf2 expression. It has potential applications in endocrine, cardiovascular, and skin diseases.
- Isolated from Centella asiatica.
- Anti-inflammatory, antioxidant, and anti-aging effects.
- Orally active.
- Inhibits inflammation, oxidation, apoptosis, and autophagy.
- Inhibits p38 MAPK and NF-κB activities.
- Exhibits anti-apoptotic properties.
- Activates Nrf2 expression to reduce neurotoxicity.
- Potential for endocrine, cardiovascular, and skin diseases.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
NP118809 is a potent N-type calcium channel blocker with an IC₅₀ of 0.11 μM, and also inhibits L-type calcium channels less potently with an IC₅₀ of 12.2 μM. It is intended for research use only.
- Potent N-type calcium channel blocker (IC₅₀ of 0.11 μM).
- Inhibits L-type calcium channels (IC₅₀ of 12.2 μM).
- Shows significant analgesic activity in the phase IIA portions of the rat formalin model (25 mg/kg, i.p.).
- Results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model (30 mg/kg, p.o.).
- Available in solid form, light yellow to yellow in color.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Urea, N-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1 | 219580-11-7 | MFCD08705327 | 99.9% | 523.7 g/mol | C28H41N7O3 | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
PD173074 is a small-molecule research compound that potently inhibits fibroblast growth factor receptor 1 (FGFR1). It shows an FGFR1 IC50 of ~25 nM, inhibits VEGFR2 with an IC50 of 100-200 nM, and demonstrates approximately 1,000-fold selectivity over PDGFR and c-Src. It is supplied for laboratory research use as an analytical/research standard.
- Potent FGFR1 inhibitor (IC50 ≈ 25 nM).
- Also inhibits VEGFR2 (IC50 100-200 nM).
- Approximately 1,000-fold selectivity for FGFR1 over PDGFR and c-Src.
- High purity (≈99.9%).
- Molecular weight 523.7 g/mol.
- CAS number 219580-11-7.
- For research use only.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Foliglurax monohydrochloride | 2133294-96-7 | 98.57% | 457.97 | 10 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Foliglurax monohydrochloride is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM), with an EC50 of 79 nM. It exhibits an antiparkinsonian effect.
- Highly selective and potent.
- Brain-penetrant mGluR4 PAM.
- EC50 of 79 nM for mGlu4.
- Exhibits antiparkinsonian effect.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC MK-8245 1030612-90-8 200mg
MK-8245 (CAS 1030612-90-8) is a potent liver-selective small molecule inhibitor of stearoyl-CoA desaturase (SCD) SCD1 catalyzes fatty acid desaturation and represents a target for treating type II diabetes obesity dyslipidemia and other metabolic disorders MK-8245 demonstrates strong inhibitory activity against rat mouse and human SCD1 with an IC50 of approximately 1 nM and displays liver-specific tissue distribution mediated by organic anion transporting polypeptides (OATPs) Animal studies revealed MK-8245 reduces blood glucose levels and hepatic triglycerides dose-dependently supporting its application in metabolic disease research
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 100g
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Methyl phenyl sulfone is a drug impurity
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC 5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide | 909089-13-0 | MFCD14733081 | 99.7% | 286.29 g/mol | C14H14N4O3 | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
SKL2001 is a small-molecule agonist of the Wnt/β-catenin signaling pathway used in biomedical research. It stabilizes intracellular β-catenin by disrupting the Axin/β-catenin interaction and has reported anti-cancer activity. The compound is supplied as a high-purity solid and exhibits high solubility in DMSO, with available protocols for in vivo formulation.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More